Deux agents du FBI sont affectés à Warehouse 13, un entrepôt centralisant tous les objets surnaturels que le gouvernement a collecté à travers les siècles. Leur mission : récupérer d'éventuels nouveaux artefacts susceptibles de mettre en danger des individus. After saving the life of the President, two secret service agents - Myka Bering and Pete Lattimer - find themselves assigned to the top secret Warehouse 13. The Warehouse is a massive, top secret facility that houses dangerous and fantastical objects. Together, Pete and Myka along with fellow agents Claudia, Steve Jinks and Warehouse caretaker Artie, must recover artifacts from around the globe before they can cause catastrophic damage.