Dwayne Johnson Boxer Santaros Seann William Scott Roland Taverner / Ronald Taverner Sarah Michelle Gellar Krysta Now Justin Timberlake Private Pilot Abilene Mandy Moore Madeline Frost-Santaros Will Sasso Fortunio Balducci Jon Lovitz Bart Bookman Beth Grant Dr. Inga Von Westphalen Jill Ritchie Shoshana Kapowski Bai Ling Serpentine Lisa K. Wyatt Teri Riley Curtis Armstrong Dr. Soberin Exx Todd Berger Bing Zinneman Rebekah Del Rio Vanessa Vera Cruz Nora Dunn Cyndi Pinziki Christopher Lambert Walter Mung John Larroquette Vaughn Smallhouse Janeane Garofalo General Teena MacArthur Abbey DiGregorio Sheena Gee Cheri Oteri Zora Charmichaels Amy Poehler Veronica Mung / Dream Miranda Richardson Nana Mae Frost Wallace Shawn Baron Von Westphalen Sab Shimono Hideo Takehashi Kevin Smith Simon Theory Wood Harris Dion Element Shannon Lee Holmes Todd Zinneman Katherine Kendall Megazeppelin Waitress Holmes Osborne Senator Bobby Frost Lou Taylor Pucci Martin Kefauver Zelda Rubinstein Dr. Katarina Kuntzler Sarah Christine Smith Dancer #1 Nicole Sciacca Dancer #2 Rachael Markarian Dancer #7 Katarina Hyde Isabella / Interpreter Sharon Jordan Secretary Paulah May Hysterical Passenger Matt McColm Bar Bouncer Eli Roth Man Who Gets Shot on Toilet Dwayne Johnson Boxer Santaros Seann William Scott Roland Taverner / Ronald Taverner Sarah Michelle Gellar Krysta Now Justin Timberlake Private Pilot Abilene Mandy Moore Madeline Frost-Santaros Will Sasso Fortunio Balducci Jon Lovitz Bart Bookman Beth Grant Dr. Inga Von Westphalen Jill Ritchie Shoshana Kapowski Bai Ling Serpentine Lisa K. Wyatt Teri Riley Curtis Armstrong Dr. Soberin Exx Todd Berger Bing Zinneman Rebekah Del Rio Vanessa Vera Cruz Nora Dunn Cyndi Pinziki Christopher Lambert Walter Mung John Larroquette Vaughn Smallhouse Janeane Garofalo General Teena MacArthur Abbey DiGregorio Sheena Gee Cheri Oteri Zora Charmichaels Amy Poehler Veronica Mung / Dream Miranda Richardson Nana Mae Frost Wallace Shawn Baron Von Westphalen Sab Shimono Hideo Takehashi Kevin Smith Simon Theory Wood Harris Dion Element Shannon Lee Holmes Todd Zinneman Katherine Kendall Megazeppelin Waitress Holmes Osborne Senator Bobby Frost Lou Taylor Pucci Martin Kefauver Zelda Rubinstein Dr. Katarina Kuntzler Sarah Christine Smith Dancer #1 Nicole Sciacca Dancer #2 Rachael Markarian Dancer #7 Katarina Hyde Isabella / Interpreter Sharon Jordan Secretary Paulah May Hysterical Passenger Matt McColm Bar Bouncer Eli Roth Man Who Gets Shot on Toilet Gary Sievers Homeless Terrorist