Eddie Murphy Det. Axel Foley Judge Reinhold Det. Sgt. William 'Billy' Rosewood Héctor Elizondo Jon Flint Gilbert R. Hill Insp. Douglas Todd Timothy Carhart Ellis Dewald Bronson Pinchot Serge Stephen McHattie Steve Fulbright Theresa Randle Janice John Saxon Orrin Sanderson Jon Tenney Levine Joey Travolta Giolito Jimmy Ortega Rondell Tim Gilbert McKee Julie Strain Annihilator Girl Joe Dante Jailer Ray Harryhausen Bar Patron Arthur Hiller Bar Patron George Lucas Disappointed Man Peter Medak Man at Corner Al Leong Car Mechanic Louis Lombardi Snake John Singleton Fireman Alan Young Uncle Dave Gregory McKinney Kimbrough Michael Bowen Fletch Rick Avery Cline Lindsey Ginter Holloway Al Green Minister Hattie Winston Mrs. Todd Tracy Melchior Ticket Booth Girl Dan Martin Cooper Steven Banks Spider Ride Operator Yareli Arizmendi Scared Kids' Mom Jeannie Epper Spider Rider William S. Taylor Spider Rider Nichole McAuley Spider Rider Meadow Williams Spider Rider Helen Martin Grandma Charles Rahi Chun Technician Elaine Kagan Sanderson's Secretary Barbet Schroeder Man in Porsche Thomas Rosales Jr. Car Mechanic (uncredited)