Diego Luna Manolo (voice) Channing Tatum Joaquin (voice) Zoe Saldana Maria (voice) Christina Applegate Mary Beth (voice) Eugenio Derbez Chato (voice) Cheech Marin Pancho Rodriguez (voice) Gabriel Iglesias Pepe Rodriguez (voice) Ron Perlman Xibalba (voice) Kate del Castillo La Muerte (voice) Ana de la Reguera Carmen Sánchez (voice) Dan Navarro Chakal (voice) Ice Cube Candle Maker (voice) Héctor Elizondo Carlos Sanchez (voice) Danny Trejo Skeleton Luis (voice) Carlos Alazraqui General Posada / Dali / Chuy (voice) Elijah Rodriguez Young Joaquin Plácido Domingo Skeleton Jorge (voice) Grey DeLisle Grandmother (voice) (as Grey Griffin) Miguel Sandoval Land of the Remembered Captain (voice) Anjelah Johnson-Reyes Adelita / Nina (voice) Gunnar Sizemore Ignacio (voice) Angélica María Sister Ana (voice) Eric Bauza Father Domingo / Cave Guardian (voice) Sandra Echeverría Claudia (voice) Tonita Castro La Muerte as Old Woman (voice) Troy Evans Old Man Hemingway (voice) Guillermo del Toro Land of the Remembered Captain's Wife (voice) Brad Booker Conductor (voice) Rosemary Alexander Additional Voices (voice) Eva Bella Additional Voices (voice) Vicki Davis Additional Voices (voice) Moosie Drier Additional Voices (voice) Maximilian Ehrenreich Manolo (voice) Cullen McCarthy Additional Voices (voice) David Michie Additional Voices (voice) Marcelo Tubert Additional Voices (voice) David Cowgill Additional Voices (voice) Elisa Gabrielli Additional Voices (voice)