Ray Romano Manny (voice) John Leguizamo Sid (voice) Denis Leary Diego (voice) Taraji P. Henson Ethel (voice) Queen Latifah Ellie (voice) Jennifer Lopez Shira (voice) Gabriel Iglesias Cholly Bear (voice) Wendy Williams Condor Mom (voice) Lili Estefan Gladys Glypto (voice) Blake Anderson Clint (voice) Keke Palmer Peaches (voice) Seann William Scott Crash (voice) Josh Peck Eddie (voice) Josh Gad Louis (voice) Wanda Sykes Granny (voice) Drake Ethan (voice) Nicki Minaj Steffie (voice) Jay Leno Fast Tony (voice) Joy Behar Eunice (voice) Alan Tudyk Milton (voice) Eddie « Piolin » Sotelo Fungus (voice) Seth Green Squint (voice) Chris Wedge Scrat (voice)