Cailey Fleming Bea Ryan Reynolds Cal John Krasinski Dad / Marshmallow (voice) Fiona Shaw Grandmother Steve Carell Blue (voice) Phoebe Waller-Bridge Blossom (voice) Louis Gossett Jr. Lewis (voice) Alan Kim Benjamin Liza Colón-Zayas Janet Bobby Moynihan Jeremy Catharine Daddario Bea’s Mom Audrey Hoffman Bea (Ages 3 & 5) Ed Herbstman Deli Guy Shauna Pinkett Hospital Receptionist David Weissmann Young Jeremy Awkwafina Bubble (voice) Emily Blunt Unicorn (voice) George Clooney Spaceman (voice) Bradley Cooper Ice (voice) Matt Damon Flower (voice) Bill Hader Banana (voice) Richard Jenkins Art Teacher (voice) Keegan-Michael Key Slime (voice) Blake Lively Octocat (voice) Sebastian Maniscalco Magician Mouse (voice) Christopher Meloni Cosmo (voice) Matthew Rhys Ghost (voice) Sam Rockwell Guardian Dog (voice) Maya Rudolph Ally (voice) Amy Schumer Gummy Bear (voice) Jon Stewart Robot (voice)