Reese Witherspoon Susan Murphy / Ginormica (voice) Seth Rogen B.O.B. (voice) Hugh Laurie Dr. Cockroach Ph.D. (voice) Will Arnett The Missing Link (voice) Kiefer Sutherland General W.R. Monger (voice) Rainn Wilson Gallaxhar (voice) Paul Rudd Derek Dietl (voice) Stephen Colbert President Hathaway (voice) Jimmy Kimmel Insectosaurus (voice) Julie White Wendy Murphy (voice) Jeffrey Tambor Carl Murphy (voice) Amy Poehler Computer (voice) Ed Helms News Reporter (voice) Renée Zellweger Katie (voice) Sean Bishop Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice) Rob Letterman Secret Service Man #1 / Lieutenant (voice) Tom McGrath Wilson (voice) Chris Miller Advisor Cole / Army Commander Jones (voice) Mike Mitchell Advisor Wedgie (voice) Kent Osborne Technician Jerry (voice) Latifa Ouaou Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice) Geoffrey Pomeroy Soldier #4 / Pilot / Soldier #3 / News Technician (voice) Lisa Stewart Bridesmaid Candy (voice) Conrad Vernon Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice) John Krasinski Cuthbert (voice) Stephen Kearin Technician Bee (voice) Reese Witherspoon Susan Murphy / Ginormica (voice) Seth Rogen B.O.B. (voice) Hugh Laurie Dr. Cockroach Ph.D. (voice) Will Arnett The Missing Link (voice) Kiefer Sutherland General W.R. Monger (voice) Rainn Wilson Gallaxhar (voice) Paul Rudd Derek Dietl (voice) Stephen Colbert President Hathaway (voice) Jimmy Kimmel Insectosaurus (voice) Julie White Wendy Murphy (voice) Jeffrey Tambor Carl Murphy (voice) Amy Poehler Computer (voice) Ed Helms News Reporter (voice) Renée Zellweger Katie (voice) Sean Bishop Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice) Rob Letterman Secret Service Man #1 / Lieutenant (voice) Tom McGrath Wilson (voice) Chris Miller Advisor Cole / Army Commander Jones (voice) Mike Mitchell Advisor Wedgie (voice) Kent Osborne Technician Jerry (voice) Latifa Ouaou Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice) Geoffrey Pomeroy Soldier #4 / Pilot / Soldier #3 / News Technician (voice) Lisa Stewart Bridesmaid Candy (voice) Conrad Vernon Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice) John Krasinski Cuthbert (voice) Stephen Kearin Technician Bee (voice) Reese Witherspoon Susan Murphy / Ginormica (voice) Seth Rogen B.O.B. (voice) Hugh Laurie Dr. Cockroach Ph.D. (voice) Will Arnett The Missing Link (voice) Kiefer Sutherland General W.R. Monger (voice) Rainn Wilson Gallaxhar (voice) Paul Rudd Derek Dietl (voice) Stephen Colbert President Hathaway (voice) Jimmy Kimmel Insectosaurus (voice) Julie White Wendy Murphy (voice) Jeffrey Tambor Carl Murphy (voice) Amy Poehler Computer (voice) Ed Helms News Reporter (voice) Renée Zellweger Katie (voice) Sean Bishop Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice) Rob Letterman Secret Service Man #1 / Lieutenant (voice) Tom McGrath Wilson (voice) Chris Miller Advisor Cole / Army Commander Jones (voice) Mike Mitchell Advisor Wedgie (voice) Kent Osborne Technician Jerry (voice) Latifa Ouaou Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice) Geoffrey Pomeroy Soldier #4 / Pilot / Soldier #3 / News Technician (voice) Lisa Stewart Bridesmaid Candy (voice) Conrad Vernon Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice) John Krasinski Cuthbert (voice) Stephen Kearin Technician Bee (voice)