Alisha Weir Matilda Wormwood Emma Thompson Agatha Trunchbull Lashana Lynch Miss Honey Stephen Graham Mr. Wormwood Andrea Riseborough Mrs. Wormwood Sindhu Vee Mrs. Phelps Carl Spencer Escapologist Lauren Alexandra Acrobat Meesha Garbett Hortensia Charlie Hodson-Prior Bruce Bogtrotter Katherine Kingsley The Acrobat's Stepsister James Laurenson Ancient / Sleeping Teacher Ann Firbank Elderly Teacher Amanda Lawrence Cook Thomas Arnold Circus Owner James Dryden Joe the School Inspector Matt Henry Doctor Alisha Weir Matilda Wormwood Emma Thompson Agatha Trunchbull Lashana Lynch Miss Honey Stephen Graham Mr. Wormwood Andrea Riseborough Mrs. Wormwood Sindhu Vee Mrs. Phelps Carl Spencer Escapologist Lauren Alexandra Acrobat Meesha Garbett Hortensia Charlie Hodson-Prior Bruce Bogtrotter Katherine Kingsley The Acrobat's Stepsister James Laurenson Ancient / Sleeping Teacher Ann Firbank Elderly Teacher Amanda Lawrence Cook Thomas Arnold Circus Owner James Dryden Joe the School Inspector Matt Henry Doctor Karen Mavundukure Midwife Ian McIntosh Anaesthetist Tim Bentinck Sports Announcer Serrana Su-Ling Bliss